About the Center of Excellence
Our Mission
Cure diabetes and reduce disease burden through modulation of metabotypes (your personal integrative metabolism profile)
Our Vision
Leverage expertise across disciplines to understand metabolic data and translate potential therapies into reality for type 1 diabetes (T1D) patients
Metabolic dysfunction drives beta cell, kidney, eye, nerve, heart and cognitive and psychosocial function in T1D. The Center of Excellence closely integrates these components via metabolomics, transcriptomic and genetic analyses to improve outcomes in persons with T1D (from the grant application).
Research that addresses the needs of patients
We’re taking a holistic view of the metabolism of T1D in order to reduce patients’ disease burden and improve patient care.
Who We Are
Our Team
Project 1: Metabotype to optimize beta cell (ß-cell) function
This project seeks to fully understand the beta cell maturation process with modulated metabolic environment.
Investigators
Scott Soleimanpour, MD
Co-Principal Investigator, Metabolism, Endocrinology, and Diabetes
Lonnie Shea, PhD
Co-Principal Investigator, Biomedical Engineering
Jason Spence, PhD
Gastroenterology
Additional members
- Daniel Clough
- Jessica King
- Feiran Li
- Anne Lietzke
- Gemma Pearson
- Jie Zhu
Project 2: Employing Artificial Intelligence (AI) to reduce hypoglycemic events
This project will leverage the continous glucose monitoring data in conjunction with patient-specific metabolic data with reinforcement learning to create an improved AI algorithm to remove human guesswork and provide more stable blood-glucose levels.
Investigators
Rodica Pop-Busui, MD, PhD
Principal Investigator, Metabolism, Endocrinology, and Diabetes
Lynn Ang, MD
Metabolism, Endocrinology, and Diabetes
Anna Mathew, MD
Nephrology
Kara Mizokami-Stout, MD, MS
Metabolism, Endocrinology, and Diabetes
Jenna Wiens, PhD
Engineering
Additional members
- Feiran Li, Biomedical Engineering
- Cynthia Plunkett, Metabolism, Endocrinology, and Diabetes
- Harry Rubin-Falcone, Engineering
Project 3: Identifying the metabotypes to reduce disease burden
This project aims to comprehensively define the metabolic profiles across multiple T1D cohorts for association analysis with a variety of organ complications, thus providing a data-driven path toward improved T1D patient care and reduced burden.
Investigators
Subramaniam Pennathur, MD
Co-Principal Investigator, Nephrology
Rodica Pop-Busui, MD, PhD
Co-Principal Investigator, Metabolism, Endocrinology, and Diabetes
Farsad Afshinnia, MD
Nephrology
Eva Feldman, MD, PhD
Neurology
Patrice Fort, PhD
Ophthalmology
Jennifer Harder, MD
Nephrology
Tom Gardner, MD, MS
Ophthalmology
Matthias Kretzler, MD
Nephrology
Thomas Wubben, MD, PhD
Ophthalmology
Additional members
- Heather Ascani, Nephrology
- Jaeman Byun, Nephrology
- Rachel Dull, Nephrology
- Bradley Godfrey, Nephrology
- John Hartman, Nephrology
- Pradeep Kayampilly, Nephrology
- Maria Larkina, Nephrology
- Rebecca Steck, Nephrology
- Rajasree Menon, Nephrology
- Ashutosh Phadte, Ophthalmology
- Rebecca Reamy, Nephrology
- Nancy Roeser, Nephrology
- Michael Rose, Nephrology
- Yang Shan, Ophthalmology
- Emily Tanner, Nephrology
- Mark Tomilo, Nephrology
- Chih-Hong Wang, Nephrology
- Zachary Wright, Nephrology
- Noel Wys, Nephrology
- Lixia Zeng, Nephrology
Project 4: Minimizing the burden of mental health in T1D
This project uses two complementary approaches for looking at psychological and cognitive outcomes in patients with T1D.
Investigators
Joyce Lee, MD, MPH
Co-Principal Investigator, Pediatrics
Rodica Pop-Busui, MD, PhD
Co-Principal Investigator, Metabolism, Endocrinology, and Diabetes
Dana Albright, PhD
Pediatrics
Brian Callaghan, MD, MS
Neurology
Anna Mathew, MD
Nephrology
Kara Mizokami-Stout, MD, MS
Metabolism, Endocrinology, and Diabetes
Additional members
- Nathaniel Putnam, Neurology
- Evan Reynolds, Neurology